• Using Skin Microbes to Lighten Pigmentation

    DH Diglucosyl Gallic Acid conversion

    Whether you like it or not, the human body is inundated with millions of microorganisms that live in a mutualistic relationship with us—in other words, each species benefits from the activity of the other. Many of the bacteria that cohabitate with us humans are not harmful and actually serve a purpose. Take for example the bacteria that live in our gut; these microbes help us digest and process our food. If something happens to our natural gut microflora, such as often occurs after a course of antibiotics that kill good and bad bacteria, our digestive system can be thrown off. We might supplement our diet with probiotics to help restore balance to our gut. Like our gut, our skin is also home to billions of microorganisms often referred to as the skin microbiota.

    The skin microbiota is continuously communicating with our epidermal cells, generating metabolites and stimulating physiological processes. Recent studies have demonstrated that the skin’s microbiota can activate specific cosmetic compounds converting them into biologically active molecules on the skin’s surface. Diglucosyl Gallic Acid, also known as Trihydroxy Benzoic Acid alpha-Glucoside (THBG) is an example of a patented molecule that when topically applied to the skin is partially converted into another form, Trihydroxy Benzoic Acid (THBA) by the skin’s microflora. THBG and THBA work together to lighten skin pigmentation and even out skin tone. Together, these two molecules not only inhibit free radical formation, which could result in hyperpigmentation, but more importantly they help stop melanogenesis. Both THBA and THBG molecules are effective at reducing pigmentation spots, as well as helping to control formation of new spots.

    As scientists continue to study the skin’s natural microbiota, it is quite apparent that studies will no longer just focus on the relationship of microbes to skin disorders and disease but will now venture into a new realm; we have just scratched the surface of understanding how our skin’s natural microbial populations can be used in conjunction with topically applied molecules to address specific skin conditions.


    • Allene Says:

      Great article! Research is everything. Would this topical be good for post
      hyperpigmentation for Acneic clients?

      February 17, 2016 at 6:11 pm
      • IDI's Response:

        Yes definitely! Formulas that contain Diglucosyl Gallic Acid can target post-inflammatory hyperpigmentation (PIH). Keep in mind, results will vary depending on the individual. As for all pigmentation concerns, patience and proper home care is key. Don’t forget, daily SPF is a must!

        February 18, 2016 at 4:56 pm
    • Kandi Says:

      Great to know. Thank you Diana. Is there a product that Dermalogica sells with both those ingredients?

      February 29, 2016 at 4:54 pm
      • IDI's Response:

        Hi Kandi! Dermalogica’s new IonActive System contains the key ingredient Diglucosyl Gallic Acid, however this system is only available for purchase to professional skin therapists. If you would like to experience the IonActive System, you can inquire with a Dermalogica skin therapist near you by visiting here.

        March 2, 2016 at 12:23 pm

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